Produktname:Maleimide-DOTA
IUPAC Name:2-[4,10-bis(carboxymethyl)-7-({[2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl]carbamoyl}methyl)-1,4,7,10-tetraazacyclododecan-1-yl]acetic acid
- CAS：1006711-90-5
- Molekulare Formel：C22H34N6O9
- Reinheit：95%+
- Katalognummer：CM338836
- Molekulargewicht：526.55
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Produkt-Details
- CAS-Nr.:1006711-90-5
- Molekulare Formel:C22H34N6O9
- Schmelzpunkt:-
- SMILES-Code:O=C(O)CN1CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(NCCN2C(C=CC2=O)=O)=O)CC1
- Dichte:
- Katalognummer:CM338836
- Molekulargewicht:526.55
- Siedepunkt:
- Mdl-Nr.:
- Lagerung:
Category Infos
- ADC-Linkers
- The ADC linker is one of the three main components of antibody drug conjugates (ADCs), linking the antibody to the effective drug (payload) through chemical bonds. ADC linkers play a key role in determining the overall success of antibody drug conjugates. One of the major challenges in developing safe and effective ADC drugs is to assemble an ideal chemical linker between the cytotoxic payload and the mAb. Well-designed ADC linkers can help the selective delivery of antibodies at the tumor site and the accurate release of cytotoxic drugs.
- Maleimides
- Thiol-maleimide is a bifunctional chemical compound that is commonly used in bioconjugation reactions to crosslink two molecules via the thiol (-SH) groups.
- Non-cleavable linkers
- Noncleavable linkers consist of stable bonds that resist proteolytic degradation and provide higher stability than the cleavable linkers.
- Carboxylic Acid
- Carboxylic acid, any of a class of organic compounds in which a carbon (C) atom is bonded to an oxygen (O) atom by a double bond and to a hydroxyl group (―OH) by a single bond.
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