Produktname:2-bromo-3-methyl-5-(trifluoromethyl)pyridine
IUPAC Name:2-bromo-3-methyl-5-(trifluoromethyl)pyridine
- CAS：1211520-05-6
- Molekulare Formel：C7H5BrF3N
- Reinheit：95%+
- Katalognummer：CM414705
- Molekulargewicht：240.02
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Produkt-Details
- CAS-Nr.:1211520-05-6
- Molekulare Formel:C7H5BrF3N
- Schmelzpunkt:-
- SMILES-Code:CC1=CC(=CN=C1Br)C(F)(F)F
- Dichte:
- Katalognummer:CM414705
- Molekulargewicht:240.02
- Siedepunkt:
- Mdl-Nr.:
- Lagerung:
Category Infos
- Pyridines
- Pyridine is a six-membered heterocyclic compound containing one nitrogen heteroatom. Pyridine and piperidine are the most frequently occurring heterocyclic building blocks in drug molecules. According to incomplete statistics, there are currently more than 180 drugs containing pyridine or piperidine structure that have been marketed, nearly 1/5 of the drugs approved for marketing in recent years contain these two structures.
- Pyridine | C5H5N | Pyridine Supplier/Distributor/Manufacturer - Chemenu
- Pyridine,Pyridine Wholesale,Pyridine for Sale,Pyridine Supplier,Pyridine Distributor,Pyridine Manufacturer
- Pyridine is a basic heterocyclic organic compound with the chemical formula C5H5N. It is structurally related to benzene, with one methine group (=CH−) replaced by a nitrogen atom. It is a highly flammable, weakly alkaline, water-miscible liquid with a distinctive, unpleasant fish-like smell.
Column Infos
- LTGO-33
- Voltage-gated sodium channels (NaVs) are responsible for action potential initiation and transmission of pain signals. NaV1.8 is specifically expressed in peripheral nociceptors and has been genetically and pharmacologically validated as a human pain target.
LTGO-33 inhibited NaV1.8 in the nM potency range and exhibited over 600-fold selectivity against human NaV1.1-NaV1.7 and NaV1.9. Unlike prior reported NaV1.8 inhibitors that preferentially interacted with an inactivated state via the pore region, LTGO-33 was state-independent with similar potencies against closed and inactivated channels.
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