Produktname:5-Fluoro-2-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline

IUPAC Name:5-fluoro-2-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline

CAS:1418128-33-2
Molekulare Formel:C13H19BFNO2
Reinheit:95%+
Katalognummer:CM209079
Molekulargewicht:251.11

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Produkt-Details

CAS-Nr.:1418128-33-2
Molekulare Formel:C13H19BFNO2
Schmelzpunkt:-
SMILES-Code:NC1=CC(F)=CC(B2OC(C)(C)C(C)(C)O2)=C1C
Dichte:
Katalognummer:CM209079
Molekulargewicht:251.11
Siedepunkt:
Mdl-Nr.:MFCD18383724
Lagerung:

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Boronic Acids and Esters
Boronic acids and boronate esters are commonly used reagents in Suzuki–Miyaura coupling chemistry. Organoboron derivatives are common reagents for C–C bond formation, either through classical palladium-mediated transformations or through other newer coupling methods. Boronic esters and acids are potential intermediates in the manufacture of many active pharmaceutical ingredients (API).
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Novartis announced new positive data from the Phase III REMIX-1 and REMIX-2 studies investigating remibrutinib - a highly selective, oral Bruton's tyrosine kinase (BTK) inhibitor - in people with chronic spontaneous urticaria (CSU) whose symptoms are inadequately controlled by H1-antihistamines. In the studies, remibrutinib met all primary and secondary endpoints at Week 12. Remibrutinib is a potential 'best-in-class' BTK inhibitor. It can covalently bind to the BTK enzyme of B cells and myeloid cells. While strongly inhibiting BTK activity, it reduces the systemic exposure of the drug and reduces the risk of adverse events and drug interactions.
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