Produktname:N-(4-Fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)pyrimidin-2-amine

IUPAC Name:N-(4-fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)pyrimidin-2-amine

CAS:1421372-94-2
Molekulare Formel:C20H16FN5O3
Reinheit:95%+
Katalognummer:CM147323
Molekulargewicht:393.38

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Produkt-Details

CAS-Nr.:1421372-94-2
Molekulare Formel:C20H16FN5O3
Schmelzpunkt:-
SMILES-Code:CN1C=C(C2=NC(NC3=CC([N+]([O-])=O)=C(F)C=C3OC)=NC=C2)C4=C1C=CC=C4
Dichte:
Katalognummer:CM147323
Molekulargewicht:393.38
Siedepunkt:
Mdl-Nr.:MFCD28167946
Lagerung:Keep in dark place, store at 2-8°C.

Column Infos

Indoles
Indole is a compound of pyrrole and benzene in parallel, also known as benzopyrrole. There are two combinations of pyrrole and benzene, called indole and isoindole, respectively. Many derivatives of indole have physiological and pharmacological activities, and can synthesize vasodilators, antihistamines, antipyretic analgesics, etc. in medicine, so indole is also a very important heterocyclic compound.
Osimertinib
TAGRISSO (osimertinib) demonstrated overwhelming efficacy benefit for patients with unresectable, Stage III EGFR-mutated lung cancer in LAURA Phase III trial.
TAGRISSO (osimertinib) is a third-generation, irreversible EGFR-TKI with proven clinical activity in NSCLC, including against central nervous system metastases. It is the first and only EGFR TKI recommended by NCCN Guidelines as an adjuvant treatment option for completely resected stage IB-IIIA, stage IIIB (T3, N2) EGFRm (exon 19 deletion, exon 21 L858R mutation) NSCLC.