Produktname:(2S,4R)-1-[(2S)-2-acetamido-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide
IUPAC Name:(2S,4R)-1-[(2S)-2-acetamido-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide
| Packungseinheit | Verfügbarer Vorrat | Preis($) | Menge |
|---|---|---|---|
| CM338813-50mg | 5-6 Weeks | ƩǺǠƅ |
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| Biological Activity |
VH 032 is an inhibitor of E3 ubiquitin ligase VHL (Kd = 185 nM). Blocks interaction between VHL and HIF-α downstream of HIF-α hydroxylation, initiating hypoxic response. VH 032 treatment causes dose dependent upregulation of HIF-target genes including CA9, GLUT1 and PHD2 in different cell lines. Cell permeable. |
| Technical Data |
Formula: C24H32N4O4S Solubility: Soluble to 100 mM in DMSO and to 100 mM in ethanol Storage: Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date. CAS No: 1448188-62-2 |
| Use |
VH-032 (VHL ligand 1) is a VHL ligand for PROTAC and potent, small molecule inhibitor of the VHL/HIF-1α interaction with Kd of 185 nM. |
| Synonyms: |
VH032 CHEMBL3344081 1448188-62-2 (2S,4R)-1-[(2S)-2-acetamido-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide N-Acetyl-3-Methyl-L-Valyl-(4r)-4-Hydroxy-N-[4-(4-Methyl-1,3-Thiazol-5-Yl)benzyl]-L-Prolinamide VH-032 (2S,4R)-1-[(2S)-2-(ACETYLAMINO)-3,3-DIMETHYLBUTANOYL]-4-HYDROXY-N~2~-[4-(4-METHYL-1,3-THIAZOL-5-YL)BENZYL]TETRAHYDRO-1H-PYRROLE-2-CARBOXAMIDE (2S,4R)-1-[(2S)-2-acetamido-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide 4w9h SCHEMBL15126287 EX-A6313 BDBM50099062 AKOS040749751 MS-28751 HY-120217 CS-0077220 EN300-26936924 Q27453846 Z3482164376 3JF |
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