Produktname:bis(dichlorophosphoryl)methane

IUPAC Name:[(dichlorophosphoryl)methyl]phosphonoyl dichloride

CAS:1499-29-2
Molekulare Formel:CH2Cl4O2P2
Reinheit:95%+
Katalognummer:CM328309
Molekulargewicht:249.77

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Produkt-Details

CAS-Nr.:1499-29-2
Molekulare Formel:CH2Cl4O2P2
Schmelzpunkt:-
SMILES-Code:O=P(CP(Cl)(Cl)=O)(Cl)Cl
Dichte:
Katalognummer:CM328309
Molekulargewicht:249.77
Siedepunkt:
Mdl-Nr.:
Lagerung:Keep in a tight congtainer and store at ambient temperature

Column Infos

Quemliclustat
Data from a phase 1b study of Quemliclustat-based regimens showed promising overall survival in treatment-naïve metastatic pancreatic cancer. Median Overall Survival was 15.7 months for all patients treated with 100 mg quemliclustat-based regimens in the ARC-8 study, which exceeds the historical benchmark data for chemotherapy alone.
Quemliclustat is an investigational, potent and selective small molecule CD73 inhibitor. CD73 is the primary enzymatic producer of immunosuppressive adenosine in the tumor microenvironment, and high CD73 expression is associated with significantly poorer prognosis in several tumor types. Quemliclustat has been shown to block the production of adenosine. Once the immunosuppressive effects of adenosine are removed, activation of antitumor immune cells may be restored, resulting in cancer cell death.