Produktname:(1R,5S)-3-Benzyl-6-nitro-3-azabicyclo[3.1.0]hexane

IUPAC Name:(1R,5S,6R)-3-benzyl-6-nitro-3-azabicyclo[3.1.0]hexane

CAS:151860-16-1
Molekulare Formel:C12H14N2O2
Reinheit:95%
Katalognummer:CM506162
Molekulargewicht:218.26

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Produkt-Details

CAS-Nr.:151860-16-1
Molekulare Formel:C12H14N2O2
Schmelzpunkt:-
SMILES-Code:O=[N+]([C@H]1[C@]2([H])CN(CC3=CC=CC=C3)C[C@]12[H])[O-]
Dichte:
Katalognummer:CM506162
Molekulargewicht:218.26
Siedepunkt:
Mdl-Nr.:MFCD23135383
Lagerung:Sealed in dry,2-8°C.

Category Infos

Piperidines
Piperidine is an azacycloalkane that is cyclohexane in which one of the carbons is replaced by a nitrogen. Although piperidine is a common organic compound, it is an immensely important class of compounds medicinally: the piperidine ring is the most common heterocyclic subunit among FDA approved drugs.
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Pyrrolidines
Pyrrolidine, also known as tetrahydropyrrole, is a saturated five-membered heterocyclic ring, which is miscible with water. Pyrrolidine exists in many alkaloids and drug molecules, such as kappa opioids, antagonists of dopamine D4 receptors, and HIV reverse transcriptase inhibitors.

Column Infos

Nanatinostat
Epstein–Barr virus (EBV) has been associated with malignant lymphomas of B-cell, T-cell, and NK-cell origin. EBV infection of lymphoma cells leads to the development of cancers with an unmet medical need. The innovative ‘Kick and Kill’ approach targets EBV with Nanatinostat and Valganciclovir, in which Nanatinostat activates Ganciclovir by inducing the expression of EBV kinase genes. Ganciclovir then converts to cytotoxic form and results in apoptosis
Histone deacetylase (HDAC) is involved in the regulation of gene expression. HDAC inhibition induces cell cycle arrest and reactivates normal expression of tumor cells. Nanatinostat is such a potent hydroxamic acid-based class I-selective HDAC inhibitor. Nanatinostat is being studied with the antiviral agent Valganciclovir in EBV-associated malignancies. Viracta Therapeutics recently reports positive topline Nana-val results from stage 1 of the NAVAL-1 Trial from both arms of the relapsed or refractory (R/R) Epstein-Barr virus-positive (EBV+) peripheral T-cell lymphoma (PTCL) cohort.

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