Produktname:(2E)-N-{2-[5-cyclopropyl-3-(pyridin-2-yl)-1H-pyrazol-1-yl]ethyl}-3-(furan-2-yl)prop-2-enamide
IUPAC Name:(2E)-N-{2-[5-cyclopropyl-3-(pyridin-2-yl)-1H-pyrazol-1-yl]ethyl}-3-(furan-2-yl)prop-2-enamide
- CAS:1798403-36-7
- Molekulare Formel:C20H20N4O2
- Reinheit:95%+
- Katalognummer:CM612475
- Molekulargewicht:348.41
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Produkt-Details
- CAS-Nr.:1798403-36-7
- Molekulare Formel:C20H20N4O2
- Schmelzpunkt:-
- SMILES-Code:O=C(NCCN1N=C(C=C1C1CC1)C1=NC=CC=C1)\C=C\C1=CC=CO1
- Dichte:
- Katalognummer:CM612475
- Molekulargewicht:348.41
- Siedepunkt:
- Mdl-Nr.:
- Lagerung:
Category Infos
- Furans
- Furan is a cyclic flammable liquid compound C4H4O that is obtained from wood oils of pines or made synthetically and is used especially in organic synthesis. Furan is aromatic because a pair of lone pair electrons of the oxygen atom in its molecule forms a large π bond in the plane of the conjugated orbital, making a total of 6 electrons in the plane of the conjugated plane, conforming to the 4n+2 structure. Aromaticity makes furan have the property of easy substitution and difficult addition. The other lone pair of electrons in oxygen stretches out. The oxygen atom itself conforms to sp2 hybridization. Due to the presence of the aromatic ring, the chemical behavior of furan is not very similar to that of other unsaturated heterocycles. The oxygen in the aromatic ring has an electron-donating effect, so the electrophilic substitution reactivity of furan is stronger than that of benzene.
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- Pyrazoles
- Pyrazoles are organic compounds of the general formula C3H3N2H. It is a five-membered heterocycle consisting of three carbon atoms and two adjacent nitrogen atoms. As an H-bond-donating heterocycle, pyrazole has been used as a more lipophilic and metabolically more stable bioisomer of phenol. Pyrazoles have attracted more and more attention due to their broad spectrum of action and strong efficacy.
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- Pyridines
- Pyridine is a six-membered heterocyclic compound containing one nitrogen heteroatom. Pyridine and piperidine are the most frequently occurring heterocyclic building blocks in drug molecules. According to incomplete statistics, there are currently more than 180 drugs containing pyridine or piperidine structure that have been marketed, nearly 1/5 of the drugs approved for marketing in recent years contain these two structures.
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- Pyridine is a basic heterocyclic organic compound with the chemical formula C5H5N. It is structurally related to benzene, with one methine group (=CH−) replaced by a nitrogen atom. It is a highly flammable, weakly alkaline, water-miscible liquid with a distinctive, unpleasant fish-like smell.
- Cyclopropanes
- Cyclopropane is the smallest cyclic compound with unique structural features and physicochemical properties, which is widely used in the design of small molecule drugs. In drug design, it is often used to increase activity, fix conformation and improve PK and water solubility. The introduction of cyclopropyl groups into drugs can change various properties of molecules, such as improving metabolic stability; increasing biological activity; enhancing drug efficacy; limiting polypeptide conformation and slowing down its hydrolysis; reducing plasma clearance; improving drug dissociation and many more. Cyclopropane rings are widely found in marketed drugs, including cardiovascular drugs, central nervous system (CNS) drugs, anticancer drugs, autoimmune and anti-inflammatory drugs.