Produktname:2',4'-Dichloro-5'H-spiro[cyclohexane-1,6'-thieno[2,3-d]pyrimidine]

IUPAC Name:2',4'-dichloro-5'H-spiro[cyclohexane-1,6'-thieno[2,3-d]pyrimidine]

CAS:1823805-22-6
Molekulare Formel:C11H12Cl2N2S
Reinheit:97%
Katalognummer:CM212287
Molekulargewicht:275.19

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Produkt-Details

CAS-Nr.:1823805-22-6
Molekulare Formel:C11H12Cl2N2S
Schmelzpunkt:-
SMILES-Code:ClC1=C(CC23CCCCC2)C(S3)=NC(Cl)=N1
Dichte:
Katalognummer:CM212287
Molekulargewicht:275.19
Siedepunkt:
Mdl-Nr.:MFCD26406909
Lagerung:

Category Infos

Pyrimidines
Pyrimidine, also known as 1,3-diazobenzene, is a heterocyclic compound with the chemical formula C4H4N2. Pyrimidine is formed by substituting 2 nitrogen atoms for 2 carbons in the meta-position of benzene. It is a diazine and retains its aromaticity. Derivatives of pyrimidine widely exist in organic macromolecular nucleic acids, and many drugs also contain pyrimidine rings. In nucleic acids, three nucleobases are pyrimidine derivatives: cytosine, thymine and uracil. There are a variety of pyrimidine-containing drugs on the market, most of which are kinase inhibitors.
Spiro Compounds
A spiro compound is a polycyclic compound in which two monocyclic rings share one carbon atom; the shared carbon atom is called a spiro atom. Spiro compounds have rigid structures, stable structures, and have special properties that general organic compounds do not possess, such as anomeric effect, spiro conjugation and spiro hyperconjugation. Compared with the monocyclic structure or the planar aromatic structure, the spiro structure has a larger three-dimensional structure; the heterocyclic spiro structure is also regarded as the biological isostere of some groups, which can change the drug to a certain extent. The water solubility, lipophilicity, dominant conformation and ADMET properties of the molecule make the optimized lead molecule easier to drug. Therefore, spiro compounds occupy a very important position in drug development.
Spiro And Bicyclic Compound
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Cyclohexanes
Cyclohexane is an organic compound with a chemical formula C6H12. It is a colorless liquid with a pungent odor, insoluble in water, and soluble in most organic solvents such as ethanol, ether, benzene, and acetone. Cyclohexyl fragments are a common structure in both natural and synthetic drugs. It can be used as both core structure and part of achiral side chain.

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