Produktname:3-(6-Bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione
IUPAC Name:3-(6-bromo-1-oxo-2,3-dihydro-1H-isoindol-2-yl)piperidine-2,6-dione
- CAS:2304513-76-4
- Molekulare Formel:C13H11BrN2O3
- Reinheit:95%+
- Katalognummer:CM621861
- Molekulargewicht:323.15
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Produkt-Details
- CAS-Nr.:2304513-76-4
- Molekulare Formel:C13H11BrN2O3
- Schmelzpunkt:-
- SMILES-Code:BrC1=CC2=C(CN(C3CCC(=O)NC3=O)C2=O)C=C1
- Dichte:
- Katalognummer:CM621861
- Molekulargewicht:323.15
- Siedepunkt:
- Mdl-Nr.:
- Lagerung:
Category Infos
- Piperidines
- Piperidine is an azacycloalkane that is cyclohexane in which one of the carbons is replaced by a nitrogen. Although piperidine is a common organic compound, it is an immensely important class of compounds medicinally: the piperidine ring is the most common heterocyclic subunit among FDA approved drugs.
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Column Infos
- MRT-2359
- Aberrant MYC pathway activation is found in cancer cells, while MYC-induced protein translation depends on GSPT1. Molecular glues targeting GSPT1 is identified as a potential treatment method in oncology. Monte Rosa’s MRT-2359 is an oral and selective molecular glue degrader of the translation termination factor GSPT1. The targeted GSPT1 degradation results in disrupting MYC-driven protein translation and reducing MYC-oncogenic signaling.
MRT-2359 is in an ongoing phase 1/2 study in MYC-driven solid tumors with a current assessment of 0.75 mg dose level. The final phase 2 dose determination and updated clinical results are anticipated in the second half of 2024. MRT-2359 previously received Fast Track Designation in patients with previously treated, metastatic NSCLC with L-MYC or N-MYC expression, Orphan Drug Designation in small cell lung cancer (SCLC), and Fast Track Designation in previously treated, metastatic SCLC with L-MYC or N-MYC expression.