Produktname:8-Fluoroadenosine
IUPAC Name:(2R,3R,4S,5R)-2-(6-amino-8-fluoro-9H-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
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| Product Overview |
8-Fluoroadenosine (8-F-Ado) is a synthetic nucleoside analogue of adenosine, an endogenous purine nucleoside found in all living organisms. 8-F-Ado is a versatile compound with a wide range of applications in biochemical and physiological research, including its use as an imaging agent for positron emission tomography (PET) and as a therapeutic agent for the treatment of cancer. 8-F-Ado has also been used as a probe for studying the enzymatic activities of adenosine-metabolizing enzymes, as a tool for studying the role of adenosine in signal transduction pathways, and as an inhibitor of adenosine-metabolizing enzymes. |
| Synthesis and Application |
The synthesis of 8-Fluoroadenosine is achieved through a two-step procedure involving the preparation of a 5-F-Ado intermediate, followed by a nucleophilic substitution reaction to form 8-Fluoroadenosine. The first step involves the preparation of 5-F-Ado from a 5-fluorouracil (5-FU) derivative and an adenosine-5'-phosphoramidite. The second step involves the reaction of 5-F-Ado with a nucleophile, such as sodium azide or sodium ethoxide, to form 8-Fluoroadenosine. The resulting 8-Fluoroadenosine is then isolated and purified by high-performance liquid chromatography (HPLC). 8-Fluoroadenosine is a useful tool for studying the enzymatic activities of adenosine-metabolizing enzymes. It has been used to study the roles of adenosine-metabolizing enzymes in signal transduction pathways, and as an inhibitor of adenosine-metabolizing enzymes. 8-Fluoroadenosine has also been used to study the physiological effects of adenosine in the central nervous system. Additionally, 8-Fluoroadenosine has been used as an imaging agent for positron emission tomography (PET), and as a therapeutic agent for the treatment of cancer. |
| Future Directions |
The potential future directions for 8-Fluoroadenosine are numerous. 8-Fluoroadenosine could be used to study the role of adenosine in the regulation of various physiological processes, such as inflammation, cell proliferation and apoptosis. 8-Fluoroadenosine could also be used to study the role of adenosine in the development of neurological and cardiovascular diseases, as well as cancer. Additionally, 8-Fluoroadenosine could be used as a therapeutic agent for the treatment of various diseases, such as cancer and neurological disorders. Finally, 8-Fluoroadenosine could be used as an imaging agent for positron emission tomography (PET). |
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