Produktname:7-chloro-5-(pentan-3-yl)pyrazolo[1,5-a]pyrimidine
IUPAC Name:7-chloro-5-(pentan-3-yl)pyrazolo[1,5-a]pyrimidine
- CAS：2416875-06-2
- Molekulare Formel：C11H14ClN3
- Reinheit：95%+
- Katalognummer：CM1075274
- Molekulargewicht：223.7
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Produkt-Details
- CAS-Nr.:2416875-06-2
- Molekulare Formel:C11H14ClN3
- Schmelzpunkt:-
- SMILES-Code:CCC(CC)C1=NC2=CC=NN2C(Cl)=C1
- Dichte:
- Katalognummer:CM1075274
- Molekulargewicht:223.7
- Siedepunkt:
- Mdl-Nr.:
- Lagerung:
Category Infos
- Pyrazolopyrimidines
- Pyrazolopyrimidine scaffolds are one of the most important heterocyclic compounds in drug discovery. This scaffold has various biological activities, among which anticancer is an important one.
Column Infos
- KB-0742
- Kronos Bio announces the first patient dosed in an expansion cohort with KB-0742 at a dose of 80mg given on a four-days-on, three-days-off schedule. This expansion cohort is enrolling platinum-resistant patients with high-grade serous ovarian cancer (HGSOC). Many cancers exhibit transcriptional deregulation, often characterized by gene amplifications of MYC family oncogene. Targeting the transcription elongation cofactor, cyclin-dependent kinase 9 (CDK9) has emerged as a therapeutic strategy to disrupt MYC oncogenic activity.
KB-0742 is an oral highly selective CDK9 inhibitor designed for the treatment of patients with MYC-amplified and other transcriptionally addicted relapsed or refractory solid tumors, including ovarian, lung, and triple-negative breast cancers.
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