Produktname:2-(8-ethyl-7-fluoro-3-(methoxymethoxy)naphthalen-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
IUPAC Name:2-[8-ethyl-7-fluoro-3-(methoxymethoxy)naphthalen-1-yl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
- CAS:2621932-48-5
- Molekulare Formel:C20H26BFO4
- Reinheit:95%+
- Katalognummer:CM1013587
- Molekulargewicht:360.23
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Produkt-Details
- CAS-Nr.:2621932-48-5
- Molekulare Formel:C20H26BFO4
- Schmelzpunkt:-
- SMILES-Code:CCC1=C(F)C=CC2=CC(OCOC)=CC(B3OC(C)(C)C(C)(C)O3)=C12
- Dichte:
- Katalognummer:CM1013587
- Molekulargewicht:360.23
- Siedepunkt:
- Mdl-Nr.:
- Lagerung:
Category Infos
- Boronic Acids and Esters
- Boronic acids and boronate esters are commonly used reagents in Suzuki–Miyaura coupling chemistry. Organoboron derivatives are common reagents for C–C bond formation, either through classical palladium-mediated transformations or through other newer coupling methods. Boronic esters and acids are potential intermediates in the manufacture of many active pharmaceutical ingredients (API).
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Column Infos
- HRS-4642
- HRS-4642 is a high affinity, selective, long-acting, and non-covalent KRAS G12D inhibitor, with an affinity constant of 0.083 nM. HRS-4642 demonstrated robust efficacy against KRAS G12D-mutant cancers both in vitro and in vivo. Importantly, in a phase 1 clinical trial, HRS-4642 exhibited promising anti-tumor activity in the escalating dosing cohorts. Furthermore, the sensitization and resistance spectrum for HRS-4642 was deciphered through genome-wide CRISPR-Cas9 screening, which unveiled proteasome as a sensitization target. HRS-4642, either as a single agent or in combination with carfilzomib, reshaped the tumor microenvironment toward an immune-permissive one.