cas 2661482-82-0|| where to buy 11-fluoro-3-methyl-3-(trifluoromethyl)-1,5,8,12-tetraazatricyclo[7.3.0.0²,⁶]dodeca-2(6),7,9,11-tetraene

Produktname:11-fluoro-3-methyl-3-(trifluoromethyl)-1,5,8,12-tetraazatricyclo[7.3.0.0²,⁶]dodeca-2(6),7,9,11-tetraene

IUPAC Name:11-fluoro-3-methyl-3-(trifluoromethyl)-1,5,8,12-tetraazatricyclo[7.3.0.0²,⁶]dodeca-2(6),7,9,11-tetraene

: CAS：2661482-82-0; Molekulare Formel：C10H8F4N4; Reinheit：95%+

: Katalognummer：CM1077632; Molekulargewicht：260.2

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Produkt-Details

: CAS-Nr.:2661482-82-0; Molekulare Formel:C10H8F4N4; Schmelzpunkt:-; SMILES-Code:CC1(CNC2=C1N1N=C(F)C=C1N=C2)C(F)(F)F; Dichte:

: Katalognummer:CM1077632; Molekulargewicht:260.2; Siedepunkt:; Mdl-Nr.:; Lagerung:

Category Infos

: Pyrazolopyrimidines; Pyrazolopyrimidine scaffolds are one of the most important heterocyclic compounds in drug discovery. This scaffold has various biological activities, among which anticancer is an important one.

Column Infos

: SGR-1505; SGR-1505 is an investigational mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) inhibitor developed by Schrödinger. MALT1 is a key mediator of the NF-κB signaling pathway and the main driver of a subset of B-cell lymphomas. Over eight billion compound designs were assessed using Schrödinger’s in-house computational MPO chemistry suite, of which only 129 were synthesized. SGR-1505 demonstrated preclinical single-agent and combination activity in B cell malignancies and showed the ability to resensitize drug-resistant tumors to BTK and BCL-2 inhibitors. The compound has completed Ph. I studies in healthy volunteers and has progressed into a Ph. I trial in patients with mature B cell malignancies.
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