Produktname:11-fluoro-3-methyl-3-(trifluoromethyl)-1,5,8,12-tetraazatricyclo[7.3.0.0²,⁶]dodeca-2(6),7,9,11-tetraene

IUPAC Name:11-fluoro-3-methyl-3-(trifluoromethyl)-1,5,8,12-tetraazatricyclo[7.3.0.0²,⁶]dodeca-2(6),7,9,11-tetraene

CAS:2661482-82-0
Molekulare Formel:C10H8F4N4
Reinheit:95%+
Katalognummer:CM1077632
Molekulargewicht:260.2

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Produkt-Details

CAS-Nr.:2661482-82-0
Molekulare Formel:C10H8F4N4
Schmelzpunkt:-
SMILES-Code:CC1(CNC2=C1N1N=C(F)C=C1N=C2)C(F)(F)F
Dichte:
Katalognummer:CM1077632
Molekulargewicht:260.2
Siedepunkt:
Mdl-Nr.:
Lagerung:

Category Infos

Pyrazolopyrimidines
Pyrazolopyrimidine scaffolds are one of the most important heterocyclic compounds in drug discovery. This scaffold has various biological activities, among which anticancer is an important one.

Column Infos

SGR-1505
SGR-1505 is an investigational mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) inhibitor developed by Schrödinger. MALT1 is a key mediator of the NF-κB signaling pathway and the main driver of a subset of B-cell lymphomas. Over eight billion compound designs were assessed using Schrödinger’s in-house computational MPO chemistry suite, of which only 129 were synthesized. SGR-1505 demonstrated preclinical single-agent and combination activity in B cell malignancies and showed the ability to resensitize drug-resistant tumors to BTK and BCL-2 inhibitors. The compound has completed Ph. I studies in healthy volunteers and has progressed into a Ph. I trial in patients with mature B cell malignancies.
Chemenu has been working to develop more compounds for drug discovery. Here are the building blocks we can provide.

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