Produktname:4-(4-Nitrophenyl)piperidine
IUPAC Name:4-(4-nitrophenyl)piperidine
- CAS：26905-03-3
- Molekulare Formel：C11H14N2O2
- Reinheit：95%+
- Katalognummer：CM275089
- Molekulargewicht：206.25
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Produkt-Details
- CAS-Nr.:26905-03-3
- Molekulare Formel:C11H14N2O2
- Schmelzpunkt:-
- SMILES-Code:O=[N+](C1=CC=C(C2CCNCC2)C=C1)[O-]
- Dichte:
- Katalognummer:CM275089
- Molekulargewicht:206.25
- Siedepunkt:
- Mdl-Nr.:MFCD06804549
- Lagerung:
Category Infos
- Piperidines
- Piperidine is an azacycloalkane that is cyclohexane in which one of the carbons is replaced by a nitrogen. Although piperidine is a common organic compound, it is an immensely important class of compounds medicinally: the piperidine ring is the most common heterocyclic subunit among FDA approved drugs.
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Column Infos
- NX-2127
- Existing BTK inhibitors directly bind to the active site of BTK and face challenges such as acquired resistance or incomplete responses over time. PROTAC-induced BTK degradation works as a novel alternative therapy for drug-resistant cancers. The latest journal Science publishes the identification of BTK mutations that are susceptible to clinical-stage BTK and IKZF1/3 degrader NX-2127.
Nurix Therapeutics’ TPD compound NX-2127 is a first-in-class, dual-function small-molecule protein degrader. It drives targeted BTK and transcription factor IKAROS (IKZF1/3) degradation through ubiquitination and proteasomal degradation, adding combined benefit. NX-2127 is under development of phase I clinical trials that shows promising results and a manageable safety profile for the treatment of relapsed/ refractory B-cell malignancies.
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