cas 2709071-60-1|| where to buy 4-Bromo-2,3-dihydro-7-(methylsulfonyl)-1H-inden-1-one

Produktname:4-Bromo-2,3-dihydro-7-(methylsulfonyl)-1H-inden-1-one

IUPAC Name:4-bromo-7-methanesulfonyl-2,3-dihydro-1H-inden-1-one

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: CAS-Nr.:2709071-60-1; Molekulare Formel:C10H9BrO3S; Schmelzpunkt:-; SMILES-Code:O=C1C=2C(=CC=C(Br)C2CC1)S(=O)(=O)C; Dichte:1.671±0.06 g/cm3

: Katalognummer:CM1078481; Molekulargewicht:289.14; Siedepunkt:494.7±45.0 °C; Mdl-Nr.:; Lagerung:

: Indenes; Indenes are useful building blocks found in a variety of biologically relevant products.

: Casdatifan; Casdatifan (AB521) is a small molecule inhibitor of the oxygen-sensing transcription factor HIF-2⍺ that has demonstrated potent antitumor activity in xenograft models of renal cell cancer (RCC). Under normal physiological conditions, HIF-2⍺ is involved in sensing oxygen availability in multiple organs. In certain tumors, particularly clear cell RCC (ccRCC), HIF-2⍺ activity is highly dysregulated as a result of genetic abnormalities in the VHL pathway. This creates a situation of pseudohypoxia and the abnormal increase in HIF-2⍺-mediated expression of a wide array of proteins involved in cancer cell proliferation and survival, treatment resistance and angiogenesis.
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