cas 2763157-90-8|| where to buy 5,7-dichloro-8-fluoro-2-(methylsulfanyl)-3H,4H-pyrido[4,3-d]pyrimidin-4-one

Produktname:5,7-dichloro-8-fluoro-2-(methylsulfanyl)-3H,4H-pyrido[4,3-d]pyrimidin-4-one

IUPAC Name:5,7-dichloro-8-fluoro-2-(methylsulfanyl)-3H,4H-pyrido[4,3-d]pyrimidin-4-one

: CAS：2763157-90-8; Molekulare Formel：C8H4Cl2FN3OS; Reinheit：95%+

: Katalognummer：CM1043992; Molekulargewicht：280.1

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CM1043992-100mg	in stock	ǺƩş
CM1043992-250mg	in stock	ǺȤŸ
CM1043992-1g	in stock	şǠȋ
CM1043992-5g	in stock	ǺƩȋȋ

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Produkt-Details

: CAS-Nr.:2763157-90-8; Molekulare Formel:C8H4Cl2FN3OS; Schmelzpunkt:-; SMILES-Code:CSC1=NC2=C(C(=O)N1)C(=NC(=C2F)Cl)Cl; Dichte:

: Katalognummer:CM1043992; Molekulargewicht:280.1; Siedepunkt:; Mdl-Nr.:; Lagerung:

Category Infos

: Pyridopyrimidines

Column Infos

: HRS-4642; HRS-4642 is a high affinity, selective, long-acting, and non-covalent KRAS G12D inhibitor, with an affinity constant of 0.083 nM. HRS-4642 demonstrated robust efficacy against KRAS G12D-mutant cancers both in vitro and in vivo. Importantly, in a phase 1 clinical trial, HRS-4642 exhibited promising anti-tumor activity in the escalating dosing cohorts. Furthermore, the sensitization and resistance spectrum for HRS-4642 was deciphered through genome-wide CRISPR-Cas9 screening, which unveiled proteasome as a sensitization target. HRS-4642, either as a single agent or in combination with carfilzomib, reshaped the tumor microenvironment toward an immune-permissive one.

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