cas 313339-92-3|| where to buy 3,5-dichloropyrazine-2-carbonitrile

Produktname:3,5-dichloropyrazine-2-carbonitrile

IUPAC Name:3,5-dichloropyrazine-2-carbonitrile

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CM102418-10g	in stock	ħǸ
CM102418-25g	in stock	Žƴħ
CM102418-100g	in stock	ƴƴǎ

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: CAS-Nr.:313339-92-3; Molekulare Formel:C5HCl2N3; Schmelzpunkt:-; SMILES-Code:ClC1=CN=C(C#N)C(Cl)=N1; Dichte:

: Katalognummer:CM102418; Molekulargewicht:173.98; Siedepunkt:276.6°C at 760 mmHg; Mdl-Nr.:MFCD13193460; Lagerung:Keep in Inert atmosphere, store at 2-8°C.

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: NX-2127; Existing BTK inhibitors directly bind to the active site of BTK and face challenges such as acquired resistance or incomplete responses over time. PROTAC-induced BTK degradation works as a novel alternative therapy for drug-resistant cancers. The latest journal Science publishes the identification of BTK mutations that are susceptible to clinical-stage BTK and IKZF1/3 degrader NX-2127.
Nurix Therapeutics’ TPD compound NX-2127 is a first-in-class, dual-function small-molecule protein degrader. It drives targeted BTK and transcription factor IKAROS (IKZF1/3) degradation through ubiquitination and proteasomal degradation, adding combined benefit. NX-2127 is under development of phase I clinical trials that shows promising results and a manageable safety profile for the treatment of relapsed/ refractory B-cell malignancies.

: NX-5948; Nurix announced the presentation of the first findings of clinical responses in the brain for NX-5948. NX-5948 is an investigational, orally bioavailable, brain penetrant, small molecule degrader of BTK. NX-5948 is currently being evaluated in a Phase 1 clinical trial in patients with relapsed or refractory B cell malignancies.