Produktname:2-(o-Tolylcarbamoyl)naphthalen-3-yl 2-chloroacetate
IUPAC Name:3-[(2-methylphenyl)carbamoyl]naphthalen-2-yl 2-chloroacetate
| Packungseinheit | Verfügbarer Vorrat | Preis($) | Menge |
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| CM140198-5g | 3-4 Weeks | ȯȐȐ |
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| Product Overview |
2-(O-tolylcarbamoyl)naphthalen-3-yl 2-chloroacetate, also known as OTCN-3-Cl, is a novel small-molecule inhibitor of the enzyme phosphoinositide 3-kinase (PI3K). |
| Synthesis Method |
2-(O-tolylcarbamoyl)naphthalen-3-yl 2-chloroacetate is synthesized by the reaction of 2-chloroacetyl chloride with o-tolylcarbamoyl naphthalene-3-carboxylic acid. The reaction is carried out in an inert atmosphere and requires a catalyst, such as pyridine, to drive the reaction. |
| Chemical Properties |
2-(O-tolylcarbamoyl)naphthalen-3-yl 2-chloroacetate is relatively easy to synthesize and purify, making it a suitable choice for laboratory experiments. |
| Synthesis and Application |
2-(O-tolylcarbamoyl)naphthalen-3-yl 2-chloroacetate has been used in a variety of scientific research applications, including the study of PI3K-mediated signaling pathways in cancer cells and other cell types. 2-(O-tolylcarbamoyl)naphthalen-3-yl 2-chloroacetate has also been used to investigate the effects of PI3K inhibition on cell proliferation, migration, and invasion in vitro. Additionally, 2-(O-tolylcarbamoyl)naphthalen-3-yl 2-chloroacetate has been used to investigate the effects of PI3K inhibition on tumor growth and metastasis in vivo. |
| Future Directions |
Further studies may investigate the effects of 2-(O-tolylcarbamoyl)naphthalen-3-yl 2-chloroacetate on other cellular processes, such as apoptosis, autophagy, and angiogenesis. Additionally, further research may investigate the effects of 2-(O-tolylcarbamoyl)naphthalen-3-yl 2-chloroacetate on other signaling pathways, such as the Wnt/β-catenin pathway, and its potential use in other therapeutic applications. Finally, further studies may investigate the mechanisms of resistance to 2-(O-tolylcarbamoyl)naphthalen-3-yl 2-chloroacetate in cancer cells, which may lead to the development of novel strategies for overcoming drug resistance. |
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