Produktname:4-Amino-6-chloro-5-hydroxypyrimidine
IUPAC Name:4-amino-6-chloropyrimidin-5-ol
- CAS:38953-42-3
- Molekulare Formel:C4H4ClN3O
- Reinheit:95%+
- Katalognummer:CM116619
- Molekulargewicht:145.55
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Produkt-Details
- CAS-Nr.:38953-42-3
- Molekulare Formel:C4H4ClN3O
- Schmelzpunkt:-
- SMILES-Code:OC1=C(Cl)N=CN=C1N
- Dichte:
- Katalognummer:CM116619
- Molekulargewicht:145.55
- Siedepunkt:312.5°C at 760 mmHg
- Mdl-Nr.:MFCD13689013
- Lagerung:Store at room temperature
Category Infos
- Pyrimidines
- Pyrimidine, also known as 1,3-diazobenzene, is a heterocyclic compound with the chemical formula C4H4N2. Pyrimidine is formed by substituting 2 nitrogen atoms for 2 carbons in the meta-position of benzene. It is a diazine and retains its aromaticity. Derivatives of pyrimidine widely exist in organic macromolecular nucleic acids, and many drugs also contain pyrimidine rings. In nucleic acids, three nucleobases are pyrimidine derivatives: cytosine, thymine and uracil. There are a variety of pyrimidine-containing drugs on the market, most of which are kinase inhibitors.
Column Infos
- Remibrutinib
- Novartis announced new positive data from the Phase III REMIX-1 and REMIX-2 studies investigating remibrutinib - a highly selective, oral Bruton's tyrosine kinase (BTK) inhibitor - in people with chronic spontaneous urticaria (CSU) whose symptoms are inadequately controlled by H1-antihistamines. In the studies, remibrutinib met all primary and secondary endpoints at Week 12. Remibrutinib is a potential 'best-in-class' BTK inhibitor. It can covalently bind to the BTK enzyme of B cells and myeloid cells. While strongly inhibiting BTK activity, it reduces the systemic exposure of the drug and reduces the risk of adverse events and drug interactions.
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