cas 64700-65-8|| where to buy Methyl (R)-2-pyrrolidone-5-carboxylate

Produktname:Methyl (R)-2-pyrrolidone-5-carboxylate

IUPAC Name:methyl (2R)-5-oxopyrrolidine-2-carboxylate

Packungseinheit	Verfügbarer Vorrat	Preis($)
CM119854-25g	in stock	ǯǯ
CM119854-100g	in stock	ưƞŢ
CM119854-500g	in stock	ȎưƄŢ

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: CAS-Nr.:64700-65-8; Molekulare Formel:C6H9NO3; Schmelzpunkt:-; SMILES-Code:O=C1N[C@@H](C(OC)=O)CC1; Dichte:

: Katalognummer:CM119854; Molekulargewicht:143.14; Siedepunkt:; Mdl-Nr.:MFCD01318621; Lagerung:Keep in a tight container and store at ambient temperature

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: Pyrrolidines; Pyrrolidine, also known as tetrahydropyrrole, is a saturated five-membered heterocyclic ring, which is miscible with water. Pyrrolidine exists in many alkaloids and drug molecules, such as kappa opioids, antagonists of dopamine D4 receptors, and HIV reverse transcriptase inhibitors.

: HRS-4642; HRS-4642 is a high affinity, selective, long-acting, and non-covalent KRAS G12D inhibitor, with an affinity constant of 0.083 nM. HRS-4642 demonstrated robust efficacy against KRAS G12D-mutant cancers both in vitro and in vivo. Importantly, in a phase 1 clinical trial, HRS-4642 exhibited promising anti-tumor activity in the escalating dosing cohorts. Furthermore, the sensitization and resistance spectrum for HRS-4642 was deciphered through genome-wide CRISPR-Cas9 screening, which unveiled proteasome as a sensitization target. HRS-4642, either as a single agent or in combination with carfilzomib, reshaped the tumor microenvironment toward an immune-permissive one.