Produktname:Methyl (R)-2-pyrrolidone-5-carboxylate

IUPAC Name:methyl (2R)-5-oxopyrrolidine-2-carboxylate

CAS:64700-65-8
Molekulare Formel:C6H9NO3
Reinheit:97%
Katalognummer:CM119854
Molekulargewicht:143.14

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Produkt-Details

CAS-Nr.:64700-65-8
Molekulare Formel:C6H9NO3
Schmelzpunkt:-
SMILES-Code:O=C1N[C@@H](C(OC)=O)CC1
Dichte:
Katalognummer:CM119854
Molekulargewicht:143.14
Siedepunkt:
Mdl-Nr.:MFCD01318621
Lagerung:Keep in a tight container and store at ambient temperature

Category Infos

Amino Acids and Peptides
Amino acids are organic compounds containing a basic amino group and an acidic carboxyl group. Because amino acids contain both amino and carboxyl groups, they can be polymerized in an end-to-end manner, removing a molecule of water to form a covalent amide bond or peptide bond. Many amino acids are linked together end to end to form a polypeptide. Amino acids and peptides are important components in the fields of medicine and life sciences.
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Pyrrolidines
Pyrrolidine, also known as tetrahydropyrrole, is a saturated five-membered heterocyclic ring, which is miscible with water. Pyrrolidine exists in many alkaloids and drug molecules, such as kappa opioids, antagonists of dopamine D4 receptors, and HIV reverse transcriptase inhibitors.

Column Infos

HRS-4642
HRS-4642 is a high affinity, selective, long-acting, and non-covalent KRAS G12D inhibitor, with an affinity constant of 0.083 nM. HRS-4642 demonstrated robust efficacy against KRAS G12D-mutant cancers both in vitro and in vivo. Importantly, in a phase 1 clinical trial, HRS-4642 exhibited promising anti-tumor activity in the escalating dosing cohorts. Furthermore, the sensitization and resistance spectrum for HRS-4642 was deciphered through genome-wide CRISPR-Cas9 screening, which unveiled proteasome as a sensitization target. HRS-4642, either as a single agent or in combination with carfilzomib, reshaped the tumor microenvironment toward an immune-permissive one.