Produktname:4-Chloro-8-methoxy-2-methylquinoline

IUPAC Name:4-chloro-8-methoxy-2-methylquinoline

CAS:64951-58-2
Molekulare Formel:C11H10ClNO
Reinheit:95%+
Katalognummer:CM146319
Molekulargewicht:207.66

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Produkt-Details

CAS-Nr.:64951-58-2
Molekulare Formel:C11H10ClNO
Schmelzpunkt:-
SMILES-Code:COC1=CC=CC2=C1N=C(C)C=C2Cl
Dichte:
Katalognummer:CM146319
Molekulargewicht:207.66
Siedepunkt:308.8°C at 760 mmHg
Mdl-Nr.:MFCD00272401
Lagerung:Store at 2-8°C.

Category Infos

Quinolines
Quinolines are an important class of biologically active heterocyclic compounds, and their derivatives usually exhibit a variety of biological activities. They can be used as antimalarial drugs and in the preparation of other antimalarial drugs. Other important activities of quinoline derivatives include inhibitory activity against EGFR-TK and antipsychotic activity. Futhermore, quinoline scaffolds are present in various drug molecules, including the antimalarial drugs aablaquine, chloroquine, mefloquine and primaquine, and the antibacterial agents gatifloxacin, levofloxacin, and moxifloxacin.
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Column Infos

Deucrictibant
Pharvaris announced positive top-line data from the CHAPTER-1 Phase 2 clinical study meeting its primary endpoint, with deucrictibant demonstrating statistically significant and clinically meaningful results of deucrictibant as an oral preventative treatment for people living with HAE. The study's primary endpoint measured the time-standardized number of investigator-confirmed HAE episodes during treatment. Participants receiving 40 mg of deucrictibant daily had an 84.5% reduction in monthly exacerbation rates compared to placebo (p=0.0008). Deucrictibant is a potent, selective, and orally available antagonist of the bradykinin B2 receptor. By inhibiting bradykinin signaling through the bradykinin B2 receptor, deucrictibant has the potential to treat the clinical signs of an HAE attack and to prevent the occurrence of attacks.
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