Produktname:2-fluoro-9H-purin-6-amine

IUPAC Name:2-fluoro-9H-purin-6-amine

CAS:700-49-2
Molekulare Formel:C5H4FN5
Reinheit:98%
Katalognummer:CM112176
Molekulargewicht:153.12

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Produkt-Details

CAS-Nr.:700-49-2
Molekulare Formel:C5H4FN5
Schmelzpunkt:-
SMILES-Code:NC1=C2N=CNC2=NC(F)=N1
Dichte:
Katalognummer:CM112176
Molekulargewicht:153.12
Siedepunkt:676.9°C at 760 mmHg
Mdl-Nr.:MFCD01632749
Lagerung:Keep in a tight container and store at ambient temperature

Category Infos

Purines
Purines are heterocyclic aromatic compounds composed of linked pyrimidine and imidazole rings. In mammals, purines are most commonly expressed in DNA and RNA (including the purines adenine and guanine), as well as single-molecule nucleotides (adenosine triphosphate (ATP), adenosine diphosphate (ADP), adenosine monophosphate (AMP), cyclic AMP, and to a lesser extent guanosine triphosphate (GTP) and cyclic guanosine monophosphate (cGMP). Purines are also key elements of the following energy metabolism molecules: reduced nicotinamide adenine dinucleotide, nicotinamide adenine dinucleotide phosphate (NADPH), and coenzyme Q. Purines can also act as direct neurotransmitters; for example, adenosine may interact with receptors to modulate cardiovascular and central nervous system (CNS) function.
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Column Infos

Islatravir and Lenacapavir
Gilead and Merck announced results from the Phase 2 clinical study evaluating the investigational combination of islatravir, an investigational nucleoside reverse transcriptase translocation inhibitor, and lenacapavir, a first-in-class , long-acting HIV capsid inhibitor. At 24 weeks, the novel investigational combination maintained a high rate (94.2%) of viral suppression (HIV-1 RNA <50 copies/mL), which is a secondary endpoint of the study. Results of the primary endpoint (HIV-1 RNA ≥50 copies/mL (c/mL) showed that one participant (1.9%) treated with islatravir and lenacapavir had a viral load of >50 copies/mL at Week 24;the participant later suppressed on islatravir and lenacapavir at Week 30.
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