Produktname:4,6-Dichloro-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine
IUPAC Name:[(2R,3R,4R,5R)-3,4-bis(acetyloxy)-5-{4,6-dichloro-1H-pyrazolo[3,4-d]pyrimidin-1-yl}oxolan-2-yl]methyl acetate
- CAS:85426-71-7
- Molekulare Formel:C16H16Cl2N4O7
- Reinheit:95%+
- Katalognummer:CM1075895
- Molekulargewicht:447.23
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Produkt-Details
- CAS-Nr.:85426-71-7
- Molekulare Formel:C16H16Cl2N4O7
- Schmelzpunkt:-
- SMILES-Code:O(C(C)=O)[C@H]1[C@@H](O[C@H](COC(C)=O)[C@H]1OC(C)=O)N2C=3C(C=N2)=C(Cl)N=C(Cl)N3
- Dichte:
- Katalognummer:CM1075895
- Molekulargewicht:447.23
- Siedepunkt:
- Mdl-Nr.:
- Lagerung:
Category Infos
- Nucleosides and Nucleotides
- Nucleosides consist of a nucleotide and a five-carbon sugar, and a nucleotide consists of a nucleotide, a five-carbon sugar, and one or more phosphate groups.
- nucleoside manufacturer
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Column Infos
- ORIC-533
- ORIC-533 is a potential best-in-class, oral inhibitor of CD73 developed by ORIC Pharmaceuticals which is currently in a Ph. Ib trial for the treatment of relapsed/refractory multiple myeloma (MM). It inhibits the CD73-mediated conversion of AMP to adenosine which generates an immunosuppressive tumor microenvironment and has the potential to be a next-generation immunotherapy. The in-depth use of co-crystal structures led the team to discover a novel set of phosphonate bioisosteres which were able to achieve bioavailability for a highly polar scaffold. The structure and discovery story of ORIC-533 were recently presented at the ACS Spring 2024 Meeting in New Orleans.
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