Produktname:8-chloro-4-(dimethylaminomethylene)-1-(2-fluoro-6-methoxy-phenyl)-3H-2-benzazepin-5-one

IUPAC Name:8-chloro-4-[(dimethylamino)methylidene]-1-(2-fluoro-6-methoxyphenyl)-4,5-dihydro-3H-2-benzazepin-5-one

CAS:869367-33-9
Molekulare Formel:C20H18ClFN2O2
Reinheit:95%+
Katalognummer:CM1018162
Molekulargewicht:372.82

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Produkt-Details

CAS-Nr.:869367-33-9
Molekulare Formel:C20H18ClFN2O2
Schmelzpunkt:-
SMILES-Code:COC1=CC=CC(F)=C1C1=NCC(=CN(C)C)C(=O)C2=CC=C(Cl)C=C12
Dichte:
Katalognummer:CM1018162
Molekulargewicht:372.82
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Alisertib
Puma Biotechnology announced the initiation of its ALISertib in CAncer (ALISCA-Lung1) Phase II trial of alisertib monotherapy for the treatment of patients with extensive stage small cell lung cancer. The ALISCA-Lung1 trial will enroll up to 60 patients with extensive stage small cell lung cancer who have progressed on or after first-line platinum-based chemotherapy and immunotherapy. The primary endpoint of the trial is objective response rate, with secondary endpoints of duration of response, disease control rate, progression-free survival and overall survival. Based upon the outcomes of the study, Puma anticipates meeting with the FDA to explore the potential for an accelerated approval pathway for alisertib in small cell lung cancer. Alisertib is an orally active and selective Aurora A kinase inhibitor, which binds to Aurora A kinase resulting in mitotic spindle abnormalities, mitotic accumulation.
Chemenu has been working to develop more compounds for drug discovery. Here are the building blocks we can provide.