Produktname:2-Ethylbutyric Acid

IUPAC Name:2-ethylbutanoic acid

CAS:88-09-5
Molekulare Formel:C6H12O2
Reinheit:95%+
Katalognummer:CM394240
Molekulargewicht:116.16

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Produkt-Details

CAS-Nr.:88-09-5
Molekulare Formel:C6H12O2
Schmelzpunkt:-
SMILES-Code:CCC(CC)C(O)=O
Dichte:
Katalognummer:CM394240
Molekulargewicht:116.16
Siedepunkt:
Mdl-Nr.:
Lagerung:

Column Infos

KB-0742
Kronos Bio announces the first patient dosed in an expansion cohort with KB-0742 at a dose of 80mg given on a four-days-on, three-days-off schedule. This expansion cohort is enrolling platinum-resistant patients with high-grade serous ovarian cancer (HGSOC). Many cancers exhibit transcriptional deregulation, often characterized by gene amplifications of MYC family oncogene. Targeting the transcription elongation cofactor, cyclin-dependent kinase 9 (CDK9) has emerged as a therapeutic strategy to disrupt MYC oncogenic activity.
KB-0742 is an oral highly selective CDK9 inhibitor designed for the treatment of patients with MYC-amplified and other transcriptionally addicted relapsed or refractory solid tumors, including ovarian, lung, and triple-negative breast cancers.