Produktname:2-Ethylbutyric Acid
IUPAC Name:2-ethylbutanoic acid
- CAS:88-09-5
- Molekulare Formel:C6H12O2
- Reinheit:95%+
- Katalognummer:CM394240
- Molekulargewicht:116.16
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Produkt-Details
- CAS-Nr.:88-09-5
- Molekulare Formel:C6H12O2
- Schmelzpunkt:-
- SMILES-Code:CCC(CC)C(O)=O
- Dichte:
- Katalognummer:CM394240
- Molekulargewicht:116.16
- Siedepunkt:
- Mdl-Nr.:
- Lagerung:
Column Infos
- KB-0742
- Kronos Bio announces the first patient dosed in an expansion cohort with KB-0742 at a dose of 80mg given on a four-days-on, three-days-off schedule. This expansion cohort is enrolling platinum-resistant patients with high-grade serous ovarian cancer (HGSOC). Many cancers exhibit transcriptional deregulation, often characterized by gene amplifications of MYC family oncogene. Targeting the transcription elongation cofactor, cyclin-dependent kinase 9 (CDK9) has emerged as a therapeutic strategy to disrupt MYC oncogenic activity.
KB-0742 is an oral highly selective CDK9 inhibitor designed for the treatment of patients with MYC-amplified and other transcriptionally addicted relapsed or refractory solid tumors, including ovarian, lung, and triple-negative breast cancers.