Produktname:4-bromo-2-chloropyrimidine

IUPAC Name:4-bromo-2-chloropyrimidine

CAS:885702-34-1
Molekulare Formel:C4H2BrClN2
Reinheit:98%
Katalognummer:CM124232
Molekulargewicht:193.43

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Produkt-Details

CAS-Nr.:885702-34-1
Molekulare Formel:C4H2BrClN2
Schmelzpunkt:-
SMILES-Code:ClC1=NC=CC(Br)=N1
Dichte:
Katalognummer:CM124232
Molekulargewicht:193.43
Siedepunkt:291.552°C at 760 mmHg
Mdl-Nr.:MFCD08272196
Lagerung:Keep in inert atmosphere, store in freezer, under -20°C.

Category Infos

Pyrimidines
Pyrimidine, also known as 1,3-diazobenzene, is a heterocyclic compound with the chemical formula C4H4N2. Pyrimidine is formed by substituting 2 nitrogen atoms for 2 carbons in the meta-position of benzene. It is a diazine and retains its aromaticity. Derivatives of pyrimidine widely exist in organic macromolecular nucleic acids, and many drugs also contain pyrimidine rings. In nucleic acids, three nucleobases are pyrimidine derivatives: cytosine, thymine and uracil. There are a variety of pyrimidine-containing drugs on the market, most of which are kinase inhibitors.

Column Infos

Encorafenib plus Binimetinib
U.S. FDA approved Pfizer's BRAFTOVI® (Encorafenib) + MEKTOVI® (Binimetinib) for the treatment of adult patients with metastatic non-small cell lung cancer (NSCLC) with a BRAF V600E mutation. The FDA's approval is based on data from the ongoing Phase 2 PHAROS clinical trial. Encorafenib is an oral small molecule BRAF kinase inhibitor, and Binimetinib is an oral small molecule MEK inhibitor targeting key proteins in the MAPK signaling pathway (RAS-RAF-MEK-ERK).
Chemenu has been working to develop more compounds for drug discovery. Here are the building blocks we can provide.