cas 920509-28-0|| where to buy 6-(4-amino-2,6-dichlorophenoxy)-4-isopropylpyridazin-3(2H)-one

Produktname:6-(4-amino-2,6-dichlorophenoxy)-4-isopropylpyridazin-3(2H)-one

IUPAC Name:6-(4-amino-2,6-dichlorophenoxy)-4-(propan-2-yl)-2,3-dihydropyridazin-3-one

: CAS：920509-28-0; Molekulare Formel：C13H13Cl2N3O2; Reinheit：95%+

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: CAS-Nr.:920509-28-0; Molekulare Formel:C13H13Cl2N3O2; Schmelzpunkt:-; SMILES-Code:CC(C)C1=CC(OC2=C(Cl)C=C(N)C=C2Cl)=NNC1=O; Dichte:

: Katalognummer:CM630981; Molekulargewicht:314.17; Siedepunkt:; Mdl-Nr.:; Lagerung:

: Pyridazines; Pyridazine, also known as o-diazobenzene, is a six-membered heterocyclic compound containing two nitrogen heteroatoms in the 1 and 2 positions with a special structure and a wide biological activity. Pyridazine is more and more popular in drug development, and a variety of pyridazine drugs have been developed and marketed. From the perspective of the therapeutic field, pyridazine drug molecules are mainly used for tumor treatment, but also involve in many therapeutic fields such as inflammation, hypertension and cardiovascular disease. With the increase and in-depth of research, pyridazine drugs will play more roles in the treatment of diseases.

: Resmetirom; Sept. 13, 2023, Madrigal Pharmaceuticals, Inc. announced that the U.S. Food and Drug Administration (FDA) has accepted for review its New Drug Application (NDA) for resmetirom for the treatment of adult patients with NASH with liver fibrosis.
Nonalcoholic steatohepatitis (NASH) is a more advanced form of nonalcoholic fatty liver disease (NAFLD).
Resmetirom is designed to target the underlying causes of NASH by reducing or eliminating liver fat (steatosis) as well as reducing liver inflammation, liver cell ballooning (hepatocyte cell death), and liver fibrosis that can lead to cirrhosis. Resmetirom is the only orally administered, small-molecule, liver-directed, truly β-selective THR agonist in Phase 3 development.

: ALG-055009; Aligos Therapeutics announced positive topline results from the Phase 2a HERALD study of ALG-055009, a thyroid hormone receptor beta (THR-β) agonist, in metabolic-dysfunction associated steatohepatitis (MASH) subjects. ALG-055009 demonstrated a favorable tolerability profile with no serious adverse events (SAEs), or clinical hyper/hypothyroidism. The majority of treatment emergent adverse events (TEAEs) were mild to moderate, with one discontinuation due to worsening insomnia in a subject with pre-existing insomnia.
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