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CFT7455

C4 Therapeutics recently announces positive results from initial study of CFT7455 in Relapsed/Refractory Multiple Myeloma (R/R MM). CFT7455 is a potent, selective MonoDAC (Monofunctional Degradation Activating Compound) degrader of IKZF1/3 gene. It binds to cereblon (CRBN) E3 ligase with high affinity in Multiple Myeloma and Non-Hodgkin Lymphoma. CFT7455 can act as a single agent or in combination with Dexamethasone for R/R MM patients.

4,4,5,5-tetramethyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3,2-dioxaborolane
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Benzo[cd]indol-2(1H)-one
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9-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-azatricyclo[6.3.1.0⁴,¹²]dodeca-1(12),4,6,8,10-pentaen-3-one
9-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-azatricyclo[6.3.1.0⁴,¹²]dodeca-1(12),4,6,8,10-pentaen-3-one
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3-Bromopiperidine-2,6-dione
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